Institute of Anatomy

About us
Research
Lehre
Collection
Body Donation
Clinical Anatomy Skills Lab
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Division Cell Biology

Ein Team der Universität Zürich möchte mit Parabelflügen eine wichtige Forschungsplattform in die Schweiz bringen. Die Testflüge sollen nicht durch öffentliche Mittel, sondern rein privat finanziert werden. Ermögliche mit einem bezahlten "Mitflug" dieses erstmalige aviatische und wissenschaftliche Ereignis in der Schweiz. "Unterstütze Forschung von morgen – erlebe die Schwerelosigkeit heute.“ Mehr unter "www.microgravity.ch"

With parabolic flights, a team from the University of Zurich is aiming to bring an important research platform to Switzerland. The test flights are to be financed privately, and not via public funding. By paying to join a flight, you can support the first aviatic and scientific venture of this kind in Switzerland. "Experience weightlessness today – support the science of tomorrow." Find out more at: www.microgravity.ch "www.microgravity.ch"

Gravitational Biology - To understand how gravity determines the architecture and function of human cells

Gravity has been a constant force throughout evolutionary history on Earth. Thus, it is one of the fundamental biological questions, if and how life on Earth requires and responds to gravity at the functional cellular and molecular level. In history, Anatomical research elucidated in detail, how the human body is constructed to withstand and to live under the gravity conditions of Earth. Now, we try to understand how the architecture and function of human cells is related to the gravitational force and therefore adapted to live on Earth. Since the 80ties, a lot of evidence has been obtained that the function of mammalian cells and of small unicellular organisms is different under the conditions of microgravity. Consequently, the question arose how normal gravity may play a role in "normal" cellular function and if gravity may provide important signals for the cell. Due to the fact that cells of the immune system are obviously influenced by altered gravity, its gravi-sensitive nature render these cells also an ideal biological model in the search for general gravi-sensitive mechanisms in mammalian cells.

Ullrich O. Thiel C. (2011) Gravitational force – triggered stress in cells of the immune system. In: Stress Challenges and Immunity in Space, Springer, Heidelberg, Germany, 187-202)

biotec

Joint division together with the University of Magdeburg, Germany

Team

Introduction

Ground-Based-Studies

Parabolic Flight Missions

Space Missions

Team:

Gruppenfoto_Ullrich

Special Equipment:

  • 2D clinostat providing „functional weightlessness“ for cell incubators (developed by German Aerospace Center DLR)
  • Hyper-g centrifuge for cell incubators
  • Fully equipped cell culture and experiment laboratory for Airbus A300 ZERO-G
    (developed by University of Magdeburg)
  • System for cell culture experiments on board of the F-5E military fighter jet

Parabolic Flight Missions

What is a Parabolic Flight ?

  • 8th DLR Parabolic Flight Campaign (2006)
    PROCASIS "Effect of microgravity on membrane proximal and chromatin-associated signal transduction in cells of the immune system"
    PI: Prof Dr. Dr. Oliver Ullrich

8th
  • 45th ESA Parabolic Flight Campaign (2006)
    SEGRIS “Signal transduction in human T cells in microgravity: expression and function of chemokines, cytokines and their receptors, epigenetic alterations”
    PI: Prof. Dr. Dr. Oliver Ullrich, Dr. Augusto Cogoli (ETHZ)
    Funding: ESA/DLR

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  • 9th DLR Parabolic Flight Campaign (2006)
    PROCASIS-2 "Effect of microgravity on membrane proximal and chromatin-associated signal transduction in cells of the immune system"
    PI: Prof. Dr. Dr. Oliver Ullrich
    Funding: DLR

9th
  • 10th ESA Parabolic Flight Campaign (2007)
    MARS-1 „Effect of microgravity on migration- and adhesion-regulating signal pathways in cells of the immune system”
    PI: Prof. Dr. Dr. Oliver Ullrich, Prof. Dr. Fengyuan Zhuang (Beijing)
    Funding: DLR

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  • 10th DLR Parabolic Flight Campaign (2007)
    CEMIS (Cell Migration in Space): “Effect of microgravity on the cytoskeleton and calcium signalling of immune cells during cell migration”
    PI: PD Dr. Kerstin Lang (Witten/Herdecke), Prof. Dr. Dr. Oliver Ullrich
    Funding:DLR

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  • 13th DLR Parabolic Flight Campaign (2009)
    MICOS-1: “Molecular, cellular and functional effects of microgravity on immune control of the central nervous system, part 1”
    PI: Prof. Dr. Dr. Oliver Ullrich, Dr. Cora Thiel
    Funding: DLR

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  • 13th DLR Parabolic Flight Campaign (2009)
    PHOX: “Short-term influences of altered gravity on the kinetics of phagocyte’s oxidative burst using the TRIPLE-LUX A PMT-clinostat for reference experiments”
    PI: Dr. Kathrin Huber, Astrid Horn, Prof. Dr. Dr. Oliver Ullrich
    Funding: DLR

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  • 14th DLR Parabolic Flight Campaign (2009)
    CLARA (Osteoclasts in Space): “Effect of microgravity on osteoclast regulation and activation”
    PI: Dr. Meliha Karsak, Prof. Dr. Dr. Oliver Ullrich
    Funding: DLR

CLARA
  • 51st ESA Parabolic Flight Campaign (2009)
    PHOX-2: “Short-term influences of altered gravity on the kinetics of phagocyte’s oxidative burst using the TRIPLE-LUX A PMT-clinostat for reference experiments”
    PI: Dr. Kathrin Huber, Astrid Horn, Prof. Dr. Dr. Oliver Ullrich
    Funding: DLR

  • 16th DLR Parabolic Flight Campaign (2010)
    MICOS-2: “Molecular, cellular and functional effects of microgravity on immune control of the central nervous system, part 2” and “Validation of microgravity experiments during parabolic manoeuvres of the military fighter jet Northrop F5-E (Aircraft-Based-Reduced-Gravity-Experimental System project, acronym: ARES)“
    PI: Prof. Dr. Dr. Oliver Ullrich Co-I: Dr. Gesine Bradacs, Dr. Cora Thiel, Capt. Marc Studer (Swiss Air Force)
    Funding: DLR

2logoMICOS-1
 
  •   ARES (Aircraft-Based-Reduced-Gravity-Experimental System)
    Parabolic Flights using Northrop F-5E military fighter jet Joint project between UZH, Swiss Air Force and RUAG Aviation
    PI: Prof. Dr. Dr. Oliver Ullrich
    Co-I: Dr. Gesine Bradacs, Capt. Marc Studer (Swiss Air Force)

Ground-Based-Studies

  • ESA-AO-2005-005 “Effect of vector-averaged gravity on signal transduction and epigenetic gene regulation in cells of the immune system“, European Space Agency (ESA), 2007-2008,
    PI: Prof. Dr. Dr. Oliver Ullrichl
  • Systematic Evaluation of the ground based (micro-) gravity simulation paradigms available in Europe. First Phase (SEGMGSPE Ph1), 2009-2010,
    WP Leader: Prof. Dr. Dr. Oliver Ullrich,Dr. Susanne Wolf, Dr. Gesine Bradacs
  • “Cellular and molecular mechanisms of gravisensitivity in human cells”, Sino-Swiss Science and Technology Cooperation Program (SSSTC), IP04-092008, 2010-2012, PI: Prof. Dr. Dr. Oliver Ullrich und Prof. Dr. Chun Yang, Beijing University of Aeronautics and Astronautics and Tsinghua University, Beijing

Space Missions

Sounding Rockets:
TEXUS49stickerneu.jpg

http://www.promocell.com/rocket-launch
http://www.mdr.de/mdr-um-zwoelf/8435410.html
http://idw-online.de/pages/de/news415613

SITI1Patch.jpg

International Space Station (ISS)

  • “Phagozytose als Biomarker für Immuntoxizität“ im Experiment “TRIPLE-LUX”,
    PI: Prof. Dr. Dr. Oliver Ullrich, Dana Simmet, Dr. Gesine Bradacs im ESA-Experiment “Gene, immune and cellular responses to single and combined Space flight conditions (Acronym: TRIPLE LUX, Prof. Dr. Bertold Hock),
    Experiment ID: 96-HEDS-04/05-101, German Aerospace Center DLR.
    Status: Flight Readines Review. Launch: tbd.
  • „Function, Adaptation and Re-Adaptation to Altered Gravity in Cells of the Immune System”,
    Acronym: FARAGIS, (ESA, ILRSA-2009-1045),
    Coordinator: Prof. Dr. Dr. Oliver Ullrich, (University of Zurich, University of Magdeburg).
    Science Team Members: Dr. Isabelle Walther (ETH Zurich), Dr. Marcel Egli (ETH Zurich), Prof. Dr. Ludmila Buravkova (IMBP, Russian Academy of Sciences, Moscow), Prof. Dr. Millie Hughes-Fulford (University of California), Prof. Dr. Meliha Karsak (University of Ulm)

Shenzhou-8 Spaceship Mission:

  • Project “Innate Immunity in microgravity” (Acronym: SITI-1), SHENZHOU-8 Space Ship Mission,
    PI: Prof. Dr. Dr. Oliver Ullrich. German Aerospace Center DLR and China Manned Space Engineering Office (CMSEO)
    Launch: 01.11.2011, 05:58 CT
    Landing: 17.11.2011, 20:38 CT

 

 

 

 

 

 

Immune surveillance of the central nervous system

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Immune surveillance of the central nervous system

During the last decades of neurobiological research, it has become clear that inflammatory reactions in the CNS, which result from a loss of control and involve a network of non-neuronal and neuronal cells, contribute significantly to the onset and progress of several major neurodegenerative diseases. On the other hand, constant immune surveillance is indispensable for neuroprotection and neurorepair, in particular during pathological conditions. To avoid inflammatory escalation, the CNS harbours an impressive arsenal of cellular and molecular mechanisms enabling strict control of immune reactions – the so-called “immune privilege”. In the last years, several in vitro, in vivo and clinical studies suggested that the endocannabinoid system participate crucially in CNS immune control and neuroprotection, therefore playing an important role in the cellular network of communication in and between the nervous and immune system during neuroinflammation and neuronal damage. In our research projects, we aim to elucidate the cellular and molecular mechanisms, how the endocannabinoid system controls and modulates CNS immune systems and how it is related and involved in inflammation, neurodegeneration, neuroprotection and neurorepair.

Gravitational and Space Biology